Building-block synthesis as a determinant of antibiotic persistence
Reduced antibiotic target activity is a major driver of antibiotic treatment failure. While this has mostly been linked to the presence of low-energy bacteria, a recent study by Taher and colleagues suggests that reduced building-block synthesis can also promote antibiotic survival during nitrogen starvation — a route distinct from energy limitation.
Authors
- Charlotte Michaux (ORCID: https://orcid.org/0000-0003-1089-7846)
- Séverin Ronneau (ORCID: https://orcid.org/0000-0002-9200-4476)
- Anaïs Padellec
Institutions
- Inserm (FR)
- Bacterial RNAs & Medicine (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-09-28
- DOI
- https://doi.org/10.1038/s41467-026-78277-3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche