Concomitant Anemia and Thrombocytopenia as Clinical Clues to Thrombotic Thrombocytopenic Purpura in Patients with Stroke or Stroke-Like Symptoms

pathic hemolytic anemia (MAHA), fever, thrombocytopenia, renal impairment, and neurological deficits [1].However, this full pentad is observed in only approximately 5 to 10% of patients, whereas thrombocytopenia and MAHA are present in most cases [2, 3].At our tertiary care hospitals, most patients with TTP were referred because of laboratory abnormalities such as anemia and thrombocytopenia, and fragmented red blood cells (RBCs) identified on peripheral blood (PB) smear at admission.In contrast, prominent neurological manifestations, including stroke-like symptoms, may obscure accompanying hematologic abnormalities, thereby hindering recognition of underlying TTP and delaying the initiation of life-saving therapeutic plasma exchange (TPE) [4-6].We retrospectively reviewed the medical records of patients admitted to two university hospitals between January 2022 and February 2026.Included patients had newly identified stroke or pre-BODY Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by the classical pentad of microangio-뇌졸중 또는 뇌졸중 유사 증상 환자에서 혈전성 혈소판감소성 자반증의 임상적 단서로서 빈혈과 혈소판감소증의 동반 Concomitant Anemia and Thrombocytopenia as Clinical Clues to Thrombotic Thrombocytopenic Purpura in Patients with Stroke or Stroke-Like Symptoms