Pulse Field Ablation: From Bench to Blueprint: Mechanistic Insights and Device Engineering and Early Clinical Translation

Pulsed field ablation has rapidly reshaped the landscape of atrial fibrillation ablation by offering a nonthermal, tissue-selective alternative to conventional thermal energy. This review highlights the scientific foundations, preclinical evidence, and engineering advances that established pulsed field ablation as a safer, faster, and more precise technology. We discuss how irreversible electroporation achieves myocardial selectivity, the pivotal studies that confirmed preservation of nearby structures, and the evolution of modern catheter systems designed for efficient and durable lesion creation. As pulsed field ablation platforms continue to mature, they are redefining procedural safety standards and expanding therapeutic possibilities in cardiac electrophysiology.

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Publication Details

Journal
Circulation Arrhythmia and Electrophysiology
Published
2026-09-25
DOI
https://doi.org/10.1161/circep.125.014597
Primary Topic
Microbial Inactivation Methods
Type
article
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article

Pulse Field Ablation: From Bench to Blueprint: Mechanistic Insights and Device Engineering and Early Clinical Translation

Sanghamitra Mohanty, Elaine Y. Wan, Luigi Di Biase, Dhanunjaya Lakkireddy et al.
Circulation Arrhythmia and Electrophysiology
Microbial Inactivation Methods
article

Pulse Field Ablation: From Bench to Blueprint: Mechanistic Insights and Device Engineering and Early Clinical Translation

Sanghamitra Mohanty, Elaine Y. Wan, Luigi Di Biase, Dhanunjaya Lakkireddy, Aashish Katapadi, MOUSSA C. MANSOUR, Oussama M. Wazni, Andrea Natale, Jalaj Garg, Jiaqi Mi
article en

Abstract

Pulsed field ablation has rapidly reshaped the landscape of atrial fibrillation ablation by offering a nonthermal, tissue-selective alternative to conventional thermal energy. This review highlights the scientific foundations, preclinical evidence, and engineering advances that established pulsed field ablation as a safer, faster, and more precise technology. We discuss how irreversible electroporation achieves myocardial selectivity, the pivotal studies that confirmed preservation of nearby structures, and the evolution of modern catheter systems designed for efficient and durable lesion creation. As pulsed field ablation platforms continue to mature, they are redefining procedural safety standards and expanding therapeutic possibilities in cardiac electrophysiology.

Circulation Arrhythmia and Electrophysiology
Heart Rhythm Society (US), Albert Einstein College of Medicine (US), Cleveland Clinic (US), Columbia University Irving Medical Center (US), Loma Linda University Health Care (US), Presbyterian Hospital (US), Texas Cardiac Arrhythmia (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 17%
Microbial Inactivation Methods
DOISourceOpenAlex
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Pulse Field Ablation: From Bench to Blueprint: Mechanistic Insights and Device Engineering and Early Clinical Translation — Sanghamitra Mohanty, Elaine Y. Wan, et al. · Circulation Arrhythmia and Electrophysiology (2026) | TGRS Research Map | TGRS