Trisomic Rescue via Allele-Specific Multiple Chromosome Cleavage Using CRISPR-Cas9 in Trisomy 21 Cells

Excellent for quickly grasping the scientific advance, methods, results, and caveats of this CRISPR chromosome-elimination work. Use it as a high-quality primer or teaching aid, then consult the primary PNAS Nexus article (and its supplements) for primary data, full methods, and figures. It correctly frames the work as a technical platform rather than an imminent clinical solution.