EUropean consensus on the Resolution Of SympToms After oesophago-gastric Resection (EUROSTAR): Peri-Operative Quality Initiative (POQI) consensus statement
Background Symptoms after upper gastrointestinal (UGI) cancer surgery are common, frequently overlap, and can substantially affect quality of life. Despite increasing recognition of this problem, there is limited standardisation in the definition, investigation and management of the postoperative conditions responsible for these symptoms. Methods A society-endorsed, European-wide series of consensus meetings was conducted using a modified Delphi process developed by the PeriOperative Quality Initiative (POQI). A multidisciplinary panel of experts from 10 European countries, selected for their expertise in UGI cancer survivorship, participated in the development of consensus-based recommendations for symptoms following major UGI cancer surgery. Independent oversight was provided by POQI, and statements and recommendations were graded using a modified GRADE methodology informed by a comprehensive literature review. Results A total of 8 statements and 13 recommendations relating to symptom monitoring and service provision after major UGI cancer surgery were developed, refined and agreed upon through a preliminary meeting and two semistructured POQI consensus meetings. Diagnostic criteria, investigation pathways and management recommendations for the common postoperative conditions encountered after UGI cancer surgery were also developed and refined through multidisciplinary discussion before achieving consensus. 16 future research priorities were identified. Conclusions The EUROSTAR consensus provides guidance on symptom monitoring, service provision and the investigation and management of common postoperative conditions following UGI cancer surgery. These recommendations represent an important step towards standardising survivorship care and supporting future research in this patient population.
Authors
- Chantal 't Hoen
- Jan Bornschein (ORCID: https://orcid.org/0000-0001-8673-3122)
- Visvakanth Sivanathan (ORCID: https://orcid.org/0000-0002-0371-6827)
- Timothy E. Miller (ORCID: https://orcid.org/0000-0001-8567-6680)
- Mark I. van Berge Henegouwen (ORCID: https://orcid.org/0000-0001-8689-3134)
- Guillaume Piessen (ORCID: https://orcid.org/0000-0001-8243-8310)
- Sowrav Barman (ORCID: https://orcid.org/0009-0008-3949-5385)
- Ben E. Byrne (ORCID: https://orcid.org/0000-0002-2183-8166)
- Arnulf H. Hölscher (ORCID: https://orcid.org/0000-0003-3400-6913)
- Jervoise N. Andreyev (ORCID: https://orcid.org/0000-0002-7165-6352)
- Marcel André Schneider (ORCID: https://orcid.org/0000-0002-6723-8879)
- Christian Geroin (ORCID: https://orcid.org/0000-0001-6095-1930)
- Christian Alexander Gutschow (ORCID: https://orcid.org/0000-0001-6171-4427)
- Jakob Hedberg (ORCID: https://orcid.org/0000-0003-1308-4592)
- Charlotte Moss (ORCID: https://orcid.org/0000-0001-6059-0223)
- Jessie Andrea Elliott (ORCID: https://orcid.org/0000-0003-4673-0386)
- Christopher John Peters (ORCID: https://orcid.org/0000-0003-2081-5701)
- Loes Noteboom
- Mark Pritchard
- Andrew J. Cockbain (ORCID: https://orcid.org/0000-0002-5859-349X)
- Pernilla Lagergren (ORCID: https://orcid.org/0000-0002-4634-0233)
- Sebastian S. Zeki (ORCID: https://orcid.org/0000-0003-1673-2663)
- Bas van Wijnhoven (ORCID: https://orcid.org/0000-0003-4738-3697)
- Kellie Owen
- Jason M. Dunn (ORCID: https://orcid.org/0000-0002-1973-6072)
- Manuel Pera Román
- Barry Laird
- Thibaud Koessler (ORCID: https://orcid.org/0000-0001-9196-9076)
- Silvia Lazzaris (ORCID: https://orcid.org/0009-0007-3381-0076)
- John Reynolds
- Kiran Purushothaman
- Mike Grocott (ORCID: https://orcid.org/0000-0002-9484-7581)
- Louis Fox
- Zainab Noor
- Donald Low (ORCID: https://orcid.org/0000-0001-8962-946X)
- Misha Luyer
- Sam H. Ahmedzai
- Stefan Mönig
- Mickael Chevallay
- Anthony Hobson
- Cathy White
- Jacopo Weindelmayer
- Jafar Jafari
- Suzanne S Gisbertz
- Magnus Nilsson
- Jesper Lagergren
- Orla Evans
- Anne-Margrethe Phillips
- Mieke Van Hemelrijck
- Andrew Davies
- Gwen Masclee
- Fredrik Klevebro
- Sheraz Markar
- Elizabeth Ward
- Fiona Huddy
- Maria Dolors Muns Cornellas
Institutions
- University of Geneva (CH)
- University of Verona (IT)
- Uppsala University (SE)
- St Thomas' Hospital (GB)
- Karolinska University Hospital (SE)
- University of Nottingham (GB)
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- King's College London (GB)
- Johannes Gutenberg University Mainz (DE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Trinity College Dublin (IE)
- Leeds Teaching Hospitals NHS Trust (GB)
- Franciscan Health (US)
- University Hospitals Bristol NHS Foundation Trust (GB)
- London Clinic (GB)
- Catharina Ziekenhuis (NL)
- St James's University Hospital (GB)
- Beaumont Hospital (IE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Edinburgh Cancer Research (GB)
- John Radcliffe Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- United Lincolnshire Hospitals NHS Trust (GB)
- Karolinska Institutet (SE)
- Centre Hospitalier Universitaire de Lille (FR)
- University of Bristol (GB)
- University of Oxford (GB)
- London Cancer (GB)
- Elisabeth-Krankenhaus Essen (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- Amsterdam Neuroscience (NL)
- MRC Weatherall Institute of Molecular Medicine (GB)
- St. Thomas Hospital (CA)
- MRC Human Immunology Unit (GB)
- Hospital Del Mar (ES)
- Duke University Health System (US)
- Royal Surrey NHS Foundation Trust (GB)
- Oxford University Hospitals NHS Trust (GB)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- St. James's Hospital (IE)
- University of Southampton (GB)
- Cancer Center Amsterdam (NL)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
- Imperial College London (GB)
- University of Amsterdam (NL)
- University of Sheffield (GB)
Publication Details
- Journal
- Gut
- Published
- 2026-09-25
- DOI
- https://doi.org/10.1136/gutjnl-2025-337109
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00