Structure-based analysis reveals a hydrophobic pocket governing P2Y 12 receptor agonist potency and selectivity

Authors

John C. Hancock (ORCID: https://orcid.org/0000-0002-7747-7814)
Paola Oliva (ORCID: https://orcid.org/0000-0002-9148-931X)
Matteo Pavan (ORCID: https://orcid.org/0000-0001-6234-5934)
Jinmyoung Joo (ORCID: https://orcid.org/0000-0003-1574-9842)
Kenneth A. Jacobson (ORCID: https://orcid.org/0000-0001-8104-1493)
Jihyun Lee (ORCID: https://orcid.org/0000-0001-8530-9418)
Masaki Terabe (ORCID: https://orcid.org/0000-0002-1777-0189)

Institutions

National Institutes of Health (US)
National Institute of Diabetes and Digestive and Kidney Diseases (US)
Institute for Basic Science (KR)
Ulsan National Institute of Science and Technology (KR)

Publication Details

Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Published: 2026-09-25
DOI: https://doi.org/10.1080/14756366.2026.2726538
Primary Topic: Adenosine and Purinergic Signaling
Type: article
Field-Weighted Citation Impact: 0.00

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article

Structure-based analysis reveals a hydrophobic pocket governing P2Y 12 receptor agonist potency and selectivity

John C. Hancock, Paola Oliva, Matteo Pavan, Jinmyoung Joo et al.

Sep 25, 2026

Journal of Enzyme Inhibition and Medicinal Chemistry

Adenosine and Purinergic Signaling

article

Structure-based analysis reveals a hydrophobic pocket governing P2Y 12 receptor agonist potency and selectivity

John C. Hancock, Paola Oliva, Matteo Pavan, Jinmyoung Joo, Kenneth A. Jacobson, Jihyun Lee, Masaki Terabe

September 25, 2026article en

Abstract

No abstract available for this paper.

Journal of Enzyme Inhibition and Medicinal ChemistryVol. 41(1)

National Institutes of Health (US), National Institute of Diabetes and Digestive and Kidney Diseases (US), Institute for Basic Science (KR), Ulsan National Institute of Science and Technology (KR)

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Adenosine and Purinergic Signaling

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