Patient-governed agentic health data exchange

Health data exchange remains constrained by fragmentation, consent burden, limited auditability, and weak incentives. We propose STARFISH, a patient-governed agentic framework where personal health agents manage granular permissions, while institutional research agents request data or execute privacy-preserving analyses. Cryptographically verifiable mandates, automated compliance, and optional benefit sharing align incentives while preserving autonomy. Agentic workflows could accelerate trials and safety surveillance, enabling trustworthy, scalable, and participatory digital health research ecosystems.

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Publication Details

Journal
npj Health Systems
Published
2026-09-25
DOI
https://doi.org/10.1038/s44401-026-00155-3
Primary Topic
Blockchain Technology Applications and Security
Type
article
Field-Weighted Citation Impact
0.00
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article

Patient-governed agentic health data exchange

Guojun Tang, Zainab Saad, Yong Chen, Jiayu Zhou et al.
npj Health Systems
Blockchain Technology Applications and Security
article

Patient-governed agentic health data exchange

Guojun Tang, Zainab Saad, Yong Chen, Jiayu Zhou, Fei Wang, Steve Drew
article en

Abstract

Health data exchange remains constrained by fragmentation, consent burden, limited auditability, and weak incentives. We propose STARFISH, a patient-governed agentic framework where personal health agents manage granular permissions, while institutional research agents request data or execute privacy-preserving analyses. Cryptographically verifiable mandates, automated compliance, and optional benefit sharing align incentives while preserving autonomy. Agentic workflows could accelerate trials and safety surveillance, enabling trustworthy, scalable, and participatory digital health research ecosystems.

npj Health SystemsVol. 3(1)
University of Calgary (CA), Cornell University (US), University of Michigan (US), University of Pennsylvania (US)
Openalex Percentile: Top 4%
Blockchain Technology Applications and Security
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Patient-governed agentic health data exchange — Guojun Tang, Zainab Saad, et al. · npj Health Systems (2026) | TGRS Research Map | TGRS