Focal neuropathies: a neuroanatomical approach to diagnosis and management

We provide a framework for clinically evaluating and managing focal neuropathies, emphasising the value of functional neuroanatomy in their diagnosis. Rather than relying solely on electrophysiology, we advocate an approach that aligns specific symptoms with known anatomical pathways to improve clinical diagnostic accuracy. We structure the paper around common clinical presentations of various mononeuropathies involving the upper and lower limbs. By categorising disorders based on their typical motor and sensory manifestations, we offer a practical approach to identifying nerve entrapments and injuries. We also explore how traditional bedside assessment can be used alongside advanced imaging to inform diagnosis and management.

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Publication Details

Journal
Practical Neurology
Published
2026-09-25
DOI
https://doi.org/10.1136/pn-2026-005108
Primary Topic
Peripheral Nerve Disorders
Type
article
Field-Weighted Citation Impact
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article

Focal neuropathies: a neuroanatomical approach to diagnosis and management

Gareth Llewelyn, Haider A. Katifi, Muhammed Ameen Noushad, Dafydd Llewelyn
Practical Neurology
Peripheral Nerve Disorders
article

Focal neuropathies: a neuroanatomical approach to diagnosis and management

Gareth Llewelyn, Haider A. Katifi, Muhammed Ameen Noushad, Dafydd Llewelyn
article en

Abstract

We provide a framework for clinically evaluating and managing focal neuropathies, emphasising the value of functional neuroanatomy in their diagnosis. Rather than relying solely on electrophysiology, we advocate an approach that aligns specific symptoms with known anatomical pathways to improve clinical diagnostic accuracy. We structure the paper around common clinical presentations of various mononeuropathies involving the upper and lower limbs. By categorising disorders based on their typical motor and sensory manifestations, we offer a practical approach to identifying nerve entrapments and injuries. We also explore how traditional bedside assessment can be used alongside advanced imaging to inform diagnosis and management.

Practical Neurology
Royal Gwent Hospital (GB), Princess Alexandra Hospital (AU), Essex Cardiothoracic Centre (GB)
Good health and well-being
Openalex Percentile: Top 12%
Peripheral Nerve Disorders
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Focal neuropathies: a neuroanatomical approach to diagnosis and management — Gareth Llewelyn, Haider A. Katifi, et al. · Practical Neurology (2026) | TGRS Research Map | TGRS