1000 highly cited articles in depression research (2016–2026)

Background: Depression is one of the world’s leading causes of disability, creating significant challenges for individuals and society. Although research in this field has grown rapidly, we still lack a complete understanding of how depression research has evolved globally over the past decade, especially regarding the long-term effects of the Coronavirus disease 2019pandemic. Methods: We collected data from the Web of Science Core Collection as of April 28, 2026. After careful screening, we included 1000 highly cited articles. Using bibliometric methods and visualization tools, we analyzed collaboration networks, keyword patterns, emerging topics, and timeline developments. Results: Our analysis shows that the United States produces more than half of the world’s high-impact depression research. Research focus has shifted from traditional theories to new areas like brain-immune connections and gut bacteria, leading to comprehensive treatment approaches that combine digital technology. The Coronavirus disease 2019 pandemic served as a major turning point, significantly reshaping research priorities and accelerating the integration of medicine and data science. Conclusions: Over the past decade, depression research has dynamically evolved in response to external challenges. Exploring basic biological mechanisms and combining knowledge from different fields have become central trends. Our comprehensive analysis provides valuable insights for planning future research, developing policies, and understanding the direction toward “multimodal integration” in depression treatment.