Multiple Agminated Papules on the Face

A middle-aged man presented with asymptomatic multiple grouped papules present bilaterally symmetrically on the face. Histopathology revealed peri-follicular, predominantly B-cell lymphoid aggregates with germinal center formation and occasional tingible body macrophages. Immunohistochemistry for Bcl-2 was positive in the peripheral mantle zone while sparing the follicle center, suggesting a reactive lymphoid follicle. Clinical differential diagnosis of facial papules can be broad, encompassing sarcoidosis, granulomatous rosacea, lupus miliaris disseminatus faciei, acneiform eruption, and eruptive benign appendageal tumors, among others. We report a rare case of pseudolymphoma clinically presenting as multiple facial papules, diagnosed through combined histopathological and immunohistochemical evaluation.

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Publication Details

Journal
International Journal of Dermatology
Published
2026-09-25
DOI
https://doi.org/10.1111/ijd.70699
Primary Topic
Cutaneous lymphoproliferative disorders research
Type
article
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article

Multiple Agminated Papules on the Face

Sushant Agrawal, Sudheer Kumar Arava, Vishal Gupta, Sunil Kumar Mallick
International Journal of Dermatology
Cutaneous lymphoproliferative disorders research
article

Multiple Agminated Papules on the Face

Sushant Agrawal, Sudheer Kumar Arava, Vishal Gupta, Sunil Kumar Mallick
article en

Abstract

A middle-aged man presented with asymptomatic multiple grouped papules present bilaterally symmetrically on the face. Histopathology revealed peri-follicular, predominantly B-cell lymphoid aggregates with germinal center formation and occasional tingible body macrophages. Immunohistochemistry for Bcl-2 was positive in the peripheral mantle zone while sparing the follicle center, suggesting a reactive lymphoid follicle. Clinical differential diagnosis of facial papules can be broad, encompassing sarcoidosis, granulomatous rosacea, lupus miliaris disseminatus faciei, acneiform eruption, and eruptive benign appendageal tumors, among others. We report a rare case of pseudolymphoma clinically presenting as multiple facial papules, diagnosed through combined histopathological and immunohistochemical evaluation.

International Journal of Dermatology
All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 9%
Cutaneous lymphoproliferative disorders research
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