Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana
This Botswana-based study evaluated the prevalence of tuberculosis (TB) infection and disease among 50 adolescents, including 25 HIV-exposed uninfected (HEU) and 25 HIV-unexposed uninfected. We found that 12% of adolescents HEU had a positive QuantiFERON-TB Gold Plus test, while no adolescent HIV-unexposed uninfected tested positive. This exploratory study found that adolescents HEU may be at increased risk for TB infection and disease, with larger studies needed.
Authors
- Gosego Masasa
- Lisa Butler (ORCID: https://orcid.org/0000-0002-7772-4555)
- Lucy Mupfumi (ORCID: https://orcid.org/0000-0002-2290-2481)
- Moyo Sikhulile (ORCID: https://orcid.org/0000-0003-3821-4592)
- Sidney Otladisa Kololo
- Leslie A. Enane (ORCID: https://orcid.org/0000-0001-8390-5881)
- Melanie M. Dubois (ORCID: https://orcid.org/0000-0001-9972-8533)
- Sara Schenkel
- Topo Makhondo
- Boitshepo Phale
- Martha Ngwaca
- Terence Mohammed
- Paul Christos
- Mackenzie Powell
- Jyoti Mathad
- Kathleen Powis
- Radhika Sundararajan
- Heather Jaspan
- Tuduetso Molefi
- Lebalang Mosiane
- Samuel Kgole
- Tanvi Sharma
- Daniel Fitzgerald
- Nyaladzi C. Maphorisa
Institutions
- Indiana University Health (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Botswana (BW)
- University of Cape Town (ZA)
- University of Washington (US)
- Queen's University (CA)
- Cornell University (US)
- Stellenbosch University (ZA)
- Massachusetts General Hospital (US)
- Center for Global Health (US)
- Ministry of Health (BW)
- Botswana Harvard AIDS Institute Partnership (BW)
- Weill Cornell Medicine (US)
- Seattle Children's Research Institute (US)
- Institute of Infectious Disease and Molecular Medicine (ZA)
- Indiana University – Purdue University Indianapolis (US)
- University of Pretoria (ZA)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-09-24
- DOI
- https://doi.org/10.1097/inf.0000000000005416
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00