Hernia mesh preparation and partially biodegradable property of hernia mesh with irregular-structured monofilaments

In this study, a partially biodegradable (PP/PGA-PCL) hernia mesh was prepared using a knitting process with a shaped cross-section monofilament with partial degradation properties. The mechanical properties, degradation characteristics, molecular structure and composition were systematically evaluated by in vitro degradation experiment, monofilament and fabric mechanical tests, and Fourier spectroscopy. The degradation test results showed that the patch lost around 20%-28.8% of its weight during experiment. And through the monofilament mechanical testing found that different ratios of PP/(PGA-PCL) on the monofilament elongation at break has a significant effect on the basis of the PP material are increased by 1–2 times. The 4 groups of test samples load are generally around 75cN, still meet the requirements of the longitudinal tensile strength of the human transverse tensile strength of the human abdominal wall (10 N/cm∼75 N/cm). What’s more, different densities and fabric structures in the mechanical properties of the patch also have a big difference in the mechanical properties of the patches. Through the patch tensile test, we found differences in patch structure of fabrics of the same density lead to a change in patch strength by a factor of about 1 to 2. Comparing with the tearing force and the top-breaking power, we also found the values of both are significantly correlated with the patch structure, and their trends are highly consistent in the bar chart. The results show that hernia patches made with this partially degradable monofilaments provide a new idea for hernia treatment.