A unique initiative: Human papillomavirus vaccination for girls in Assam, India

Abstract: The first human papillomavirus (HPV) vaccination initiative was undertaken in Assam, with an indigenously made vaccine in India, “CERVAVAC,” in association with a nonprofit organization during March 2025–February 2026. The main objective was to initiate HPV vaccination among girls from 9 years and above to create widespread awareness and prevent cervical cancer. A total of 2000 girls received the vaccine with a total of 3800 doses. Persistent infection with high-risk HPV genotypes is the principal etiological factor for cervical cancer, and prophylactic vaccination can prevent up to 90% of cases. A survey in Assam showed less that 1% had previously vaccinated against HPV, and awareness was 39% among students of elite academic institutions due to lower socioeconomic status, population heterogeneity, and deeply rooted sociocultural beliefs significantly contributing to less screening and vaccination coverage. Nongovernmental organizations played a pivotal role in spreading awareness and vaccination all over India, but this vaccination drive was the first initiative in the state of Assam. The impact was an infinite transformation of mindset to a finite measurable outcome, setting a national record of highest vaccination by a nongovernmental organization within 1 year time.