Chlorobenzenes and the hypothalamic–pituitary–adrenal axis: a level-stratified systematic review of preclinical evidence

Protocol and pre-screening materials for a systematic review of preclinical evidence on chlorobenzene exposure and hypothalamic–pituitary–adrenal (HPA) axis function in vertebrate models. Reported according to PRISMA 2020; risk of bias assessed with SYRCLE's tool and the ToxRTool; synthesis follows SWiM. Evidence is organised by level of biological organisation (organism, tissue, cell) rather than by compound alone.