Polysomnography and neurocognition in children with Fontan circulation

Abstract Children with single-ventricle post-Fontan palliation often struggle with chronic hypoxaemia and adverse neurodevelopmental outcomes. This brief report describes cardiorespiratory parameters obtained through polysomnography in 48 children and adolescents with Fontan circulation and investigates associations between polysomnography and neuropsychological testing in a subset of 26 patients. We found intermittent hypoxaemia was associated with parent-reported inattention symptoms, and severity of obstructive sleep apnoea with poorer visual-motor integration skills (all p < 0 .05). Prompt recognition and treatment of these modifiable risk factors may have the potential to improve neurodevelopmental outcomes and quality of life.