The renaissance of information retrieval and the limitations of artificial intelligence

This paper critically examines the limitations of generative AI in medicine and challenges the popular narrative that multimodality alone can rescue its current shortcomings. It argues for a shift toward evidence-based AI grounded in structured, high-quality clinical data rather than unsupported generation. Retrieval-Augmented Generation (RAG) is presented as a promising framework for improving grounding, attribution, and explainability, though its clinical use remains underdeveloped. The paper also highlights the risks of overreliance on commercial cloud infrastructure, particularly with respect to cost, dependency, and research autonomy. It calls for foundational research in multimodal retrieval and specialized models to enable AI systems that are safe, explainable, clinically grounded, and genuinely useful in medicine.

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Publication Details

Journal
BMC Medical Informatics and Decision Making
Published
2026-09-25
DOI
https://doi.org/10.1186/s12911-026-03858-7
Primary Topic
Artificial Intelligence Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

The renaissance of information retrieval and the limitations of artificial intelligence

H.R. Tizhoosh
BMC Medical Informatics and Decision Making
Artificial Intelligence Applications
article

The renaissance of information retrieval and the limitations of artificial intelligence

H.R. Tizhoosh
article en

Abstract

This paper critically examines the limitations of generative AI in medicine and challenges the popular narrative that multimodality alone can rescue its current shortcomings. It argues for a shift toward evidence-based AI grounded in structured, high-quality clinical data rather than unsupported generation. Retrieval-Augmented Generation (RAG) is presented as a promising framework for improving grounding, attribution, and explainability, though its clinical use remains underdeveloped. The paper also highlights the risks of overreliance on commercial cloud infrastructure, particularly with respect to cost, dependency, and research autonomy. It calls for foundational research in multimodal retrieval and specialized models to enable AI systems that are safe, explainable, clinically grounded, and genuinely useful in medicine.

BMC Medical Informatics and Decision Making
Mayo Clinic in Florida (US)
Openalex Percentile: Top 9%
Artificial Intelligence Applications
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The renaissance of information retrieval and the limitations of artificial intelligence — H.R. Tizhoosh · BMC Medical Informatics and Decision Making (2026) | TGRS Research Map | TGRS