Harnessing multiple immune pathways to drive anti-tumor activity

“As a physician, my goal is to develop a therapy that all intended patients, and healthcare systems, can afford and deliver.”Abi Pinchbeck, Commissioning Editor, Cell & Gene Therapy Insights , speaks with Dr Frank Borriello, CEO, Alloplex Biotherapeutics, about a non-engineered, autologous approach to cancer immunotherapy. They discuss the ENLYST platform and multi-pathway immune cell activation, the SUPLEXA manufacturing process, comparability across variable autologous starting material, durability, and persistence, and the potential of decentralized manufacturing to improve patient access. They also explore how in vivo and ex vivo CAR-T fit into the evolving cell therapy landscape.

Authors

Publication Details

Journal
Cell and Gene Therapy Insights
Published
2026-09-24
DOI
https://doi.org/10.18609/cgti.2026.107
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

Harnessing multiple immune pathways to drive anti-tumor activity

Frank Borriello
Cell and Gene Therapy Insights
CAR-T cell therapy research
article

Harnessing multiple immune pathways to drive anti-tumor activity

Frank Borriello
article en

Abstract

“As a physician, my goal is to develop a therapy that all intended patients, and healthcare systems, can afford and deliver.”Abi Pinchbeck, Commissioning Editor, Cell & Gene Therapy Insights , speaks with Dr Frank Borriello, CEO, Alloplex Biotherapeutics, about a non-engineered, autologous approach to cancer immunotherapy. They discuss the ENLYST platform and multi-pathway immune cell activation, the SUPLEXA manufacturing process, comparability across variable autologous starting material, durability, and persistence, and the potential of decentralized manufacturing to improve patient access. They also explore how in vivo and ex vivo CAR-T fit into the evolving cell therapy landscape.

Cell and Gene Therapy InsightsVol. 12(9)
Openalex Percentile: Top 15%
CAR-T cell therapy research
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