Molecular Design and Anticancer Activities of Small‐Molecule BRAF Inhibitors: A Medicinal Chemistry Perspective

ABSTRACT BRAF is a cytoplasmic serine‐threonine protein kinase that plays a critical role in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by mutation in human cancers. Many classes of B‐Raf small molecule inhibitors have been identified. In this review, we will highlight typical BRAF inhibitors developed during these decades and provide a reference for the exploration of more potential BRAF inhibitors in the future.