Recent Updates in Surgical and Non‐Surgical Management of Peyronie's Disease: Implications for Modern Clinical Practice

ABSTRACT The management of Peyronie's Disease (PD) remains a clinical challenge to urologists due to its dynamic and heterogeneous nature, variable psychosocial burden, with wide‐ranging treatments, both non‐surgical and surgical. Recent advances in Peyronie's disease (PD) include refined classification systems like PTNM that help facilitate personalized treatment. While Penile Traction Therapy (PTT) is the mainstay for noninvasive treatment of PD, Collagenase clostridium histolyticum (CCH) therapy remains the main FDA‐approved non‐surgical option in the US, recently showing effectiveness even in acute phase, ventral, and calcified cases. Surgical techniques, including plication, grafting, and prostheses, are evolving with new minimally invasive methods demonstrating promise. Overall, progress in classification, therapies, and surgical options allows for more tailored and effective patient care.

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Journal
Trends in Urology & Men s Health
Published
2026-09-22
DOI
https://doi.org/10.1002/tre.70042
Primary Topic
Sexual function and dysfunction studies
Type
article
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article

Recent Updates in Surgical and Non‐Surgical Management of Peyronie's Disease: Implications for Modern Clinical Practice

Mohit Khera, William A. Brown, Justin K. Achua, Jeffrey C. Morrison et al.
Trends in Urology & Men s Health
Sexual function and dysfunction studies
article

Recent Updates in Surgical and Non‐Surgical Management of Peyronie's Disease: Implications for Modern Clinical Practice

Mohit Khera, William A. Brown, Justin K. Achua, Jeffrey C. Morrison, Beatriz S. Hernandez, Thiago Pardini Furtado
article en

Abstract

ABSTRACT The management of Peyronie's Disease (PD) remains a clinical challenge to urologists due to its dynamic and heterogeneous nature, variable psychosocial burden, with wide‐ranging treatments, both non‐surgical and surgical. Recent advances in Peyronie's disease (PD) include refined classification systems like PTNM that help facilitate personalized treatment. While Penile Traction Therapy (PTT) is the mainstay for noninvasive treatment of PD, Collagenase clostridium histolyticum (CCH) therapy remains the main FDA‐approved non‐surgical option in the US, recently showing effectiveness even in acute phase, ventral, and calcified cases. Surgical techniques, including plication, grafting, and prostheses, are evolving with new minimally invasive methods demonstrating promise. Overall, progress in classification, therapies, and surgical options allows for more tailored and effective patient care.

Trends in Urology & Men s HealthVol. 17(5)
University of Colorado Hospital (US), Baylor College of Medicine (US), University of Colorado Denver (US)
Good health and well-being
Openalex Percentile: Top 10%
Sexual function and dysfunction studies
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Recent Updates in Surgical and Non‐Surgical Management of Peyronie's Disease: Implications for Modern Clinical Practice — Mohit Khera, William A. Brown, et al. · Trends in Urology & Men s Health (2026) | TGRS Research Map | TGRS