DELE1 is dispensable for heat-stress-induced ISR during mouse spermatogenesis but has implications for lipid metabolism
Germ cell specific Dele1 knockout in mice fails to impair male fertility and heat stress induced integrated stress response, while proteomic profiling implicates DELE1 as a candidate modulator of germ cell lipid metabolism.
Authors
- Peng Dai (ORCID: https://orcid.org/0009-0001-0915-3033)
- Deqiang Ding (ORCID: https://orcid.org/0000-0002-7959-5654)
- Zhicheng Wu
- Yilan Teng
- Zixuan Li (ORCID: https://orcid.org/0009-0000-9617-3982)
- Mingxing Zhang (ORCID: https://orcid.org/0009-0000-1244-6278)
- Hongwen Zhu
Institutions
- Guangzhou University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Biology of Reproduction
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1093/biolre/ioag206
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00