EPIGENETICS - EWAS AND SURROGATE BIOMARKERS

In this presentation, I will introduce array-based DNA methylation profiling in large cohort studies. I will discuss the similarities and differences between genome- and epigenome-wide association studies along with the development of DNA methylation biomarkers of ageing, lifestyle, proteins and disease. This will include an overview of tissue-specific biomarkers. I will also highlight alternative approaches to quantifying DNA methylation, such as sequencing-based approaches.