JAK3 regulates PIP5K expression, promotes PIP2 generation and Ca2+ driven platelet activation in arterial thrombosis
Phospholipase C (PLC)-evoked rising intracellular Ca2+-levels are a prerequisite for platelet activation with subsequent thrombosis. The protein-tyrosine kinase Janus kinase 3 (JAK3) regulates phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-levels in platelets, thus significantly mediating activation-dependent platelet function and arterial thrombosis.
Authors
- Betül Fındık (ORCID: https://orcid.org/0000-0001-5071-9484)
- Harald Schulze (ORCID: https://orcid.org/0000-0003-1285-6407)
- Patrick Münzer (ORCID: https://orcid.org/0000-0001-5357-038X)
- Sascha Geue
- Mailin-Christin Manke (ORCID: https://orcid.org/0000-0001-9197-4940)
- Melina Fischer (ORCID: https://orcid.org/0009-0009-1086-9176)
- Oliver Borst (ORCID: https://orcid.org/0000-0003-4002-4085)
- Robert Ahrends (ORCID: https://orcid.org/0000-0003-0232-3375)
- Julia Skokowa (ORCID: https://orcid.org/0000-0002-4399-2324)
- Dominik Rath (ORCID: https://orcid.org/0000-0002-5008-2572)
- Frederic Stein (ORCID: https://orcid.org/0000-0002-4181-9448)
- Kristina Mott (ORCID: https://orcid.org/0000-0002-3223-6857)
- Ferdinand Kollotzek (ORCID: https://orcid.org/0000-0002-6715-064X)
- Tobias Geisler (ORCID: https://orcid.org/0000-0002-8864-6038)
- Monika Zdanytė (ORCID: https://orcid.org/0000-0002-0754-8015)
- Britta Walker
- Michael Lämmerhofer (ORCID: https://orcid.org/0000-0002-1318-0974)
- Gundula Dorothea Lingens (ORCID: https://orcid.org/0009-0009-8099-5493)
- Meinrad Gawaz
Institutions
- University of Vienna (AT)
- University of Würzburg (DE)
- Universitätsklinikum Tübingen (DE)
- Universitätsklinikum Würzburg (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Blood
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1182/blood.2026033425
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00