Multimodal Facial Rejuvenation Using Integrated Radiofrequency, Microneedle Radiofrequency, and Dynamic Muscle Stimulation: A Prospective Randomized Controlled Trial

BACKGROUND Facial aging is a multilayered process involving the skin, subcutaneous tissue, and facial musculature. OBJECTIVE To evaluate the efficacy and safety of an integrated radiofrequency (RF), microneedle radiofrequency (MNRF), and dynamic muscle stimulation (DMSt) approach for facial rejuvenation. MATERIALS AND METHODS Participants with moderate-to-severe facial wrinkles received 3 treatment sessions at 1-month intervals using a combined radiofrequency (RF), microneedle radiofrequency (MNRF), and dynamic muscle stimulation (DMSt) device, with clinical outcomes and safety evaluated during follow-up. RESULTS Significant improvement in facial wrinkles and overall appearance was observed at 1, 3, and 6 months after 3 treatments. All treated participants demonstrated improvement on the Global Aesthetic Improvement Scale (GAIS), whereas no improvement was observed in untreated controls ( p < .001). Fitzpatrick-Goldman Wrinkle and Elastosis Scale (FWES) scores and patient satisfaction also improved. Although partial attenuation of effects was noted at later follow-up, outcomes remained superior to controls. Adverse events were mild, transient, and well tolerated. CONCLUSION The combined RF, MNRF, and DMSt approach achieves significant, albeit partial, improvement with a favorable safety profile by targeting both skin and underlying musculature.