Heptafluorobutyric Acid-Induced Cross-Dehydrogenative Coupling Reactions of 1,2,4-Triazines. Part 2: p-Coupling with Arylamines
Abstract A heptafluorobutyric acid-induced cross-dehydrogenative coupling reaction of arylamines with 1,2,4-triazines has been described. This metal-free protocol enables regioselective para-C–H hetarylation of diverse arylamines including well-known fluorophore scaffolds, such as triphenylamine, carbazole, and phenothiazine, with easily accessible 1,2,4-triazines under mild conditions. This approach has potential for drug development and material design.
Authors
- Dmitry S. Kopchuk (ORCID: https://orcid.org/0000-0002-0397-4033)
- Ainur D. Sharapov (ORCID: https://orcid.org/0000-0003-1582-5462)
- Igor А. Khalymbadzha (ORCID: https://orcid.org/0000-0002-8043-8023)
- Anton N. Tsmokalyuk (ORCID: https://orcid.org/0000-0001-9333-4197)
- Ramil F. Fatykhov (ORCID: https://orcid.org/0000-0003-3129-8658)
- Elisaveta M. Gurina
- Alexander S. Novikov
- Anastasia P. Potapova (ORCID: https://orcid.org/0009-0004-5970-6080)
- Vasiliy S. Gaviko
Institutions
- National Research University Higher School of Economics (RU)
- Ural Federal University (RU)
- Immanuel Kant Baltic Federal University (RU)
- Sirius University of Science and Technology (RU)
- M.N. Mikheev Institute of Metal Physics (RU)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1021/acs.joc.6c00932
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00