Expansion of Dengue Virus Serotype 3 Genetic Diversity and Changing Serotype Composition in Brazil
Brazil is the most hyperendemic country for dengue, with historically dominant circulation of DENV-1 and DENV-2. Bayesian phylodynamic analyses of 489 Brazilian DENV-3 genomes, including 84 newly generated sequences, reveal a recent and sustained increase in the effective population size of DENV-3 associated with the recent introduction and expansion of the 3III_B.3.2 lineage. This increase coincides with a sharp rise in the proportion of laboratory-confirmed dengue cases attributed to DENV-3 among records with available serotype information from 2024 onwards and a shift in serotype dynamics in 2025, suggesting a change in serotype distribution and a potential risk of renewed DENV-3 outbreaks, particularly in populations with limited prior exposure to this serotype.
Authors
- James Siqueira Pereira (ORCID: https://orcid.org/0000-0003-1893-8956)
- Maria Carolina Elias (ORCID: https://orcid.org/0000-0002-0501-8280)
- Mariana Matos Roll (ORCID: https://orcid.org/0000-0002-3405-4168)
- Gleissy Adriane Lima Borges (ORCID: https://orcid.org/0000-0003-4782-8190)
- Gabriel Montenegro de Campos (ORCID: https://orcid.org/0000-0001-5181-415X)
- Tiago Souza Salles (ORCID: https://orcid.org/0000-0002-5822-1426)
- Igor Santana Ribeiro
- Cicileia Correia da Silva
- Cláudia Renata dos Santos Barros (ORCID: https://orcid.org/0000-0002-1582-2010)
- Glaucilene da Silva Costa (ORCID: https://orcid.org/0000-0002-4096-9436)
- Svetoslav Nanev Slavov (ORCID: https://orcid.org/0000-0003-0805-6140)
- Felicidade Mota Pereira (ORCID: https://orcid.org/0000-0002-6938-161X)
- Isabela Carvalho Brcko (ORCID: https://orcid.org/0000-0002-6036-520X)
- Talita Adelino (ORCID: https://orcid.org/0000-0002-1471-0084)
- Marta Lamounier Moura Vargas Corgozinho (ORCID: https://orcid.org/0000-0001-9421-6619)
- Luíz Carlos Júnior Alcântara (ORCID: https://orcid.org/0000-0002-6769-9931)
- Marta Giovanetti (ORCID: https://orcid.org/0000-0002-5849-7326)
- Mariana de Souza Araújo (ORCID: https://orcid.org/0009-0007-6794-8196)
- Valnete das Graças Dantas Andrade
- Elaine Cristina de Oliveira (ORCID: https://orcid.org/0000-0002-5224-7078)
- Alex Ranieri Jerônimo Lima (ORCID: https://orcid.org/0000-0002-5283-7502)
- Stephanni Figueiredo da Silva
- Sandra Coccuzzo Sampaio (ORCID: https://orcid.org/0000-0001-6257-3531)
- Brenno Vinicius Martins Henrique (ORCID: https://orcid.org/0000-0001-9778-9033)
- Vinícius Carius de Souza (ORCID: https://orcid.org/0000-0001-8075-3253)
- Arabela Leal E Silva de Mello (ORCID: https://orcid.org/0000-0001-6174-4108)
- Melissa Palmieri
- Aline de Andrade Freund
- Juan Gabriel Carvalho de Araújo
Institutions
- Universidade Federal de Rondônia (BR)
- Escola Bahiana de Medicina e Saúde Pública (BR)
- Università Campus Bio-Medico (IT)
- Universidade de São Paulo (BR)
- Universidade do Estado do Pará (BR)
- Instituto Butantan (BR)
- Universidade Brasil (BR)
- Universidade Federal de Mato Grosso (BR)
- Ezequiel Dias Foundation (BR)
- Governo do Distrito Federal (BR)
- Secretaria de Estado de Educação do Distrito Federal (BR)
- Secretaria Municipal de Saúde (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Pathogens
- Published
- 2026-09-21
- DOI
- https://doi.org/10.3390/pathogens15091001
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00