Molecularly Imprinted MXene Composites for Advanced Photoelectrochemical Molecular Sensing

ABSTRACT Molecularly imprinted MXene composites represent an emerging and highly promising approach for advancing photoelectrochemical (PEC) molecular sensing applications. Integrating the unique features of MXene, including their excellent electrical conductivity, large surface area, and tunable surface chemistry, with the molecular recognition properties of molecularly imprinted polymer (MIP), significantly improves the sensitivity and specificity of PEC detection. These intrinsic properties of MXene facilitate efficient photoinduced charge separation, rapid interfacial electron transfer, and enhanced photocurrent generation, thereby improving the overall PEC sensing performance for molecular detection applications, including small molecules, organic contaminants, and pesticides. We discuss various MIP‐MXene composites and their synergistic effects on electron transfer, molecular recognition, and signal amplification in PEC sensing applications. Particular emphasis is placed on recent advances in fabrication methods, sensing principles, and the capabilities of these composite materials for clinical, environmental, and food safety applications. Key challenges such as scalability, stability, and biocompatibility are also discussed, along with future directions for the efficient integration of MIP‐MXene composites into PEC sensing platforms. With the potential to transform real‐time sensing, these materials are poised to become essential components of next‐generation PEC sensing devices.