Classification of older pulmonary tuberculosis patients based on symptom clusters and differences in medication adherence: a latent class analysis
{"To":[0],"explore":[1],"the":[2,13,21,78,81,87,95,116,126,133,163,169,195,217,224,230,244,250,265,271,290,324,333],"symptom":[3,25,112,166,177],"experience":[4,113],"subtypes":[5,26,167],"of":[6,16,51,80,84,89,119,171,200,220,233,243,302,335,359],"older":[7,55,343],"pulmonary":[8,58,346],"tuberculosis":[9,59,65],"(PTB)":[10],"patients":[11,56,128,222,288,344],"during":[12],"intensive":[14],"phase":[15],"treatment":[17,121,355],"and":[18,27,45,72,103,135,154,168,197,207,249,337],"to":[19,110,161,287],"examine":[20,162],"association":[22,164],"between":[23,41,165],"different":[24],"patient":[28],"medication":[29],"adherence.":[30,356],"This":[31,348],"study":[32,39,326],"was":[33,92,108,123,238,270,313,340,350],"a":[34,144,328,366],"prospective,":[35],"multicenter,":[36],"observational":[37],"cohort":[38],"conducted":[40],"September":[42],"1,":[43],"2025,":[44],"December":[46],"31,":[47],"2025.":[48],"A":[49],"total":[50],"300":[52],"newly":[53],"diagnosed":[54],"with":[57,143,276,345,353],"were":[60,159],"consecutively":[61],"recruited":[62],"from":[63],"4":[64],"wards":[66],"at":[67],"Nantong":[68],"Sixth":[69],"People's":[70,75],"Hospital":[71],"Nanjing":[73],"Gaochun":[74],"Hospital.":[76],"At":[77,216],"end":[79],"first":[82],"month":[83,118,219],"anti-tuberculosis":[85],"treatment,":[86,120,221],"burden":[88,199],"17":[90],"symptoms":[91,201,339],"assessed":[93,124],"using":[94,132],"Pulmonary":[96],"Tuberculosis":[97,141],"Patient":[98],"Symptom":[99,182],"Cluster":[100],"Assessment":[101],"Scale,":[102],"Latent":[104],"Class":[105,179,186,209],"Analysis":[106],"(LCA)":[107],"employed":[109],"identify":[111],"subtypes.":[114],"In":[115,323],"third":[117,218],"adherence":[122,235,278,305,370],"for":[125,140,262,368],"285":[127],"who":[129],"completed":[130],"follow-up":[131],"self-developed":[134],"validated":[136],"Treatment":[137],"Adherence":[138],"Scale":[139],"(TAS-TB),":[142],"score":[145],">":[146],"36":[147],"points":[148],"defined":[149],"as":[150,203,365],"\\"good":[151,172],"adherence\\".":[152,173],"Univariate":[153],"multivariate":[155],"logistic":[156],"regression":[157],"analyses":[158],"used":[160],"status":[170],"LCA":[174],"identified":[175,341],"three":[176],"subtypes:":[178],"1:":[180],"Low":[181],"Burden":[183],"(42.7%,":[184],"n=128);":[185],"2:":[187],"High":[188,211],"Psychogastrointestinal":[189,226,267],"Symptoms":[190],"(30.7%,":[191],"n=92),":[192],"characterized":[193,331],"by":[194,332],"co-occurrence":[196,334],"high":[198],"such":[202],"depression,":[204],"anxiety,":[205],"nausea,":[206],"vomiting;":[208],"3:":[210],"Respiratory":[212],"Symptoms-Dominant":[213],"(26.6%,":[214],"n=80).":[215],"in":[223,289,295],"\\"High":[225,251,266],"Symptoms\\"":[227,268],"subtype":[228,247,253,269,297,330,349],"had":[229,298],"lowest":[231],"rate":[232],"good":[234,304],"(45.7%),":[236],"which":[237],"significantly":[239,299],"lower":[240,300],"than":[241],"that":[242],"\\"Low":[245,291],"Burden\\"":[246,292],"(77.3%)":[248],"Respiratory\\"":[252],"(60.0%)":[254],"(P<0.001).":[255],"Multivariate":[256],"analysis":[257],"showed":[258],"that,":[259],"after":[260],"controlling":[261],"confounding":[263],"factors,":[264],"factor":[272,317],"most":[273],"strongly":[274],"associated":[275,316,352],"poor":[277,354],"(aOR":[279],"=":[280],"0.24,":[281],"95%":[282,319],"CI:":[283,320],"0.13–0.45,":[284],"P<0.001).":[285],"Compared":[286],"subtype,":[293],"those":[294],"this":[296,360],"odds":[301,307],"achieving":[303],"(adjusted":[306],"ratio":[308],"0.24).":[309],"Co-morbid":[310],"diabetes":[311],"mellitus":[312],"another":[314],"independently":[315],"(aOR=0.52,":[318],"0.28–0.97,":[321],"P=0.037).":[322],"present":[325],"sample,":[327],"specific":[329],"psychological":[336],"gastrointestinal":[338],"among":[342],"tuberculosis.":[347],"closely":[351],"Early":[357],"identification":[358],"symptomatic":[361],"phenotype":[362],"may":[363],"serve":[364],"reference":[367],"stratified":[369],"management":[371],"interventions.":[372]}
Authors
- Xiaoqing Cheng (ORCID: https://orcid.org/0000-0001-5321-1459)
- Yilan Cai
- Yanglin Rui
Institutions
- Nantong University (CN)
- Second People's Hospital of NanTong (CN)
- Gaochun People's Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1186/s12879-026-14486-x
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00