Facial Lifting and Skin Rejuvenation Using a Dual‐Wavelength Picosecond Nd: YAG Laser in Asian Skin: A Prospective Pilot Study

ABSTRACT Background Fractional picosecond lasers promote nonablative skin rejuvenation by inducing dermal remodeling through photomechanical effects. However, prospective clinical evidence regarding dual‐wavelength picosecond Nd:YAG laser systems remains limited. Objective To evaluate the efficacy and safety of a dual‐wavelength picosecond Nd:YAG laser for facial laxity and skin quality. Methods In this prospective, single‐arm pilot study, 20 adults underwent three treatments at 4‐week intervals using sequential 1064‐ and 532‐nm picosecond laser. Outcomes included Cutometer parameters (R2, R5, R7), melanin index (MI), erythema index (EI), imaging analysis, physician‐assessed GAIS, participant satisfaction, and adverse events. Results All participants completed the study. R5 and R7 improved from Week 4 onward, while R2 improved significantly at Weeks 8 and 12. MI and EI decreased significantly at Week 12. Imaging analysis showed significant improvements in pores, wrinkles, pigmentation, skin tone, and gloss. Week‐12 GAIS and participant satisfaction scores were 4.70 ± 0.57 and 4.50 ± 0.76, respectively. Adverse events were limited to transient erythema and transient worsening of preexisting malar melasma in two participants, which resolved spontaneously. Conclusion Dual‐wavelength picosecond Nd:YAG laser treatment progressively improved skin elasticity, skin tone, and overall skin quality with a favorable safety profile, supporting its potential for nonablative facial lifting and skin rejuvenation.