Interface‐Engineered Ti 3 C 2 MXene/Co‐MOF Nanozymes With Electron Fast‐Track for Synergistic Pathogen Eradication and Wound Repair

ABSTRACT Despite the promise of catalytic nanozymes in treating multidrug‐resistant (MDR) bacterial infections, their antibacterial efficiency is often constrained by limited catalytic activity and inefficient interfacial coupling between functional components. Herein, we engineered a Ti 3 C 2 MXene/Cobalt‐based Metal‐Organic Framework (Co‐MOF) heterostructured nanozyme (CMX) via interfacial Ti–O–Co coordination between conductive Ti 3 C 2 MXene and redox‐active Co‐MOF. Different from physically mixed MXene/MOF systems or externally stimulated antibacterial nanozymes, CMX was designed to strengthen interfacial catalytic synergy, modulate the local catalytic environment of Co sites, and boost Fenton‐like reactive oxygen species (ROS) generation under mild conditions. Consequently, the interface‐engineered CMX system exhibits strong bactericidal activity, markedly reducing the viability of Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ), and methicillin‐resistant S. aureus ( MRSA ) by >99% within 2 h at 200 µg mL −1 . In vivo evaluations in rat infected wound models demonstrate that topical CMX + H 2 O 2 treatment reduced bacterial burden and showed no obvious systemic toxicity within the tested observation period. Furthermore, the CMX‐based treatment alleviated local inflammation, promoted collagen deposition and angiogenesis‐associated marker expression, and accelerated wound closure, reaching ∼95.2% closure by Day 10. This Ti–O–Co interface‐engineered nanozyme provides a promising topical non‐antibiotic strategy for antibacterial therapy and infected wound repair.