Photoinduced Decarboxylative Radioiodination of (Hetero)aryl Carboxylic Acids
Abstract A direct photoinduced and Cu(II)-mediated decarboxylative radioiodination method was described. This transformation features a broad substrate scope and excellent functional group tolerance, affording the corresponding radiolabeled (hetero)arenes in good to excellent radiochemical yields. Furthermore, this methodology enables the late-stage radioiodination of complex bioactive molecules, providing a versatile platform for the development of radioiodinated radiopharmaceuticals.
Authors
- Xiaojun Zeng (ORCID: https://orcid.org/0000-0002-9425-4882)
- Junbin Han (ORCID: https://orcid.org/0000-0002-2781-7710)
- Pengfei Song (ORCID: https://orcid.org/0000-0002-9103-6345)
- Ze Wang (ORCID: https://orcid.org/0000-0003-0645-4831)
- Jun Qian (ORCID: https://orcid.org/0000-0003-3119-7670)
- Haiyang Zhao (ORCID: https://orcid.org/0009-0002-3167-6479)
- Mingwei Wang
- Kaizhe Zhang
- Yu Zhang
Institutions
- Nanchang University (CN)
- Donghua University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1021/acs.orglett.6c03279
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00