Nickel-Catalyzed Diastereoselective Cascade Cyclization/Cross-Coupling for the Synthesis of Dibenzazepines

Abstract Here, we report a nickel-catalyzed system for intramolecular cascade cyclization/cross-coupling, affording diverse dibenzazepines with exclusive diastereoselectivity. Reversible dissociation of a labile ligand generates an open coordination site, enabling alkene binding and a key eight- to nine-membered nickelacycle transition state, supported by DFT calculations. The method features broad substrate scope and good functional group tolerance and provides straightforward access to dibenzazepines.