Dual‐Targeted Biomimetic MoSe 2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

ABSTRACT Peri‐implant diseases (PID) remain major threats to titanium implant longevity, largely due to insufficient soft tissue integration (STI), which weakens the biological seal and promotes a pathogenic–immunological amplification loop involving early Staphylococcus aureus colonization and oxidative stress‐induced macrophage dysfunction. Here, we developed a dual‐targeting biomimetic nanozyme platform by camouflaging molybdenum diselenide (MoSe 2 ) nanoflowers with membranes derived from S. aureus ‐pre‐stimulated macrophages (SPMM). This biomimetic design couples S. aureus –targeting of SPMM with the photothermal activity of MoSe 2 to achieve targeted contact‐enhanced bacterial eradication, while integrating macrophage‐targeting of SPMM with reactive oxygen species (ROS)‐scavenging activity of MoSe 2 to alleviate oxidative stress in macrophages. By disrupting the pathogenic–immunological amplification loop, MoSe 2 @SPMM reshaped a pro‐regenerative peri‐implant immune microenvironment. In a rat implantation model, near‐infrared (NIR)‐triggered MoSe 2 @SPMM suppressed bacterial colonization, promoted macrophage reprogramming, and preserved endothelial and fibroblast functions, thereby enhancing angiogenesis, matrix remodeling, connective tissue attachment, and integrin‐mediated tissue–implant adhesion. This biomimetic nanozyme strategy provides a rational framework for coordinating pathogen control and immune regulation to promote peri‐implant STI.