Single and multiple oral giant cell fibromas: a case report and review of the literature

Giant cell fibroma (GCF), a benign fibrous growth, accounts for about 4.7% of all oral benign or reactive fibrous growths. GCF commonly occurs in Caucasians, with a minor female predilection and a peak occurrence in the first three decades of life. Clinically, gingival nodules that are roughly 1 cm in diameter are commonly seen. Diagnosis relies on histopathological features, as clinical features are not sufficient on their own. Here, we report Egyptian case series of three female and two male patients with GCFs, with age range from 15 to 64 years. Three of them occurred in relatively uncommon locations (tongue and buccal mucosa). Some of the patients had esthetic concerns and others had masticatory problems. The first case was multiple, which is extremely rare. The lesions were removed surgically and depending on the histopathological features, a final diagnosis of giant cell fibroma was established. It is crucial for dentists to identify GCFs due to their frequent occurrence and to consider them when making a differential diagnosis with other fibrous hyperplastic diseases of the oral cavity, not only solitary lesions but also multiple lesions.