Cycloserine inhibits glutamate decarboxylase from Mycobacterium tuberculosis
. Both cycloserine enantiomers break the internal aldimine bond between PLP and the conserved Lys277 residue, forming a previously unrecognised PLP-oxime product and subsequently inhibiting catalysis. Given that PLP-dependent enzymes are promising drug targets, understanding the chemical behaviour of PLP is essential for developing selective inhibitors.
Authors
- Ondřej Bulvas (ORCID: https://orcid.org/0000-0003-3945-4408)
- Michal Tupec (ORCID: https://orcid.org/0000-0003-2371-4850)
- Jan Snášel
- Jiří Dostál
- Iva Pichová
Institutions
- Czech Academy of Sciences (CZ)
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
Publication Details
- Journal
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1080/14756366.2026.2707854
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00