GPR35-positive mast cells are enriched in primary sclerosing cholangitis and show an enhanced secretory phenotype
OBJECTIVE: dependent mast cell biology relevant for cholangitis and biliary fibrosis. METHODS: knockdown were determined by DESeq2 and gene set enrichment analysis. Selected cytokines, TNFα and IL13, were measured by qRT-PCR and ELISA. Mast cell-cholangiocyte interaction was studied in transwell co-culture with H69 cell line. RESULTS: dependent manner. CONCLUSION: supports a pro-secretory mast cell phenotype with potential relevance to biliary fibrosis. The increased infiltration of GPR35 positive mast cells in PSC near bile ducts could be a target for biliary fibrogenesis.
Authors
- Georg Schneditz (ORCID: https://orcid.org/0000-0001-6734-5861)
- Nicole C. Kaneider (ORCID: https://orcid.org/0000-0002-6079-4389)
- Xiaojun Jiang (ORCID: https://orcid.org/0000-0003-1503-5997)
- Johannes R. Hov (ORCID: https://orcid.org/0000-0002-5900-8096)
- Jørgen D. Rønneberg
- Joshua E. Elias
- Tom H. Karlsen
- Brian K. Chung
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- University of Cambridge (GB)
- Cambridge School (PT)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Scandinavian Journal of Gastroenterology
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1080/00365521.2026.2731959
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00