Tumor growth going FAR with KRAS FARnesylation-induced phase separation
RAS at the plasma membrane relay signals from cell-surface receptors to intracellular pathways. In Cell , Wang et al. 1 show that farnesylation drives KRAS cytoplasmic condensation, contributing to its maturation. They identify statins as candidates to overcome resistance to KRAS-targeted therapies.
Authors
- Stéphan Vagner (ORCID: https://orcid.org/0000-0003-1452-7164)
- Sidhant Kalia
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1016/j.celrep.2026.117924
- Primary Topic
- Advanced Electron Microscopy Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00