Care of the Infant With Congenital Cytomegalovirus Infection: Clinical Report
This clinical report addresses recognized knowledge gaps regarding congenital CMV infection (cCMV) in infants and expands on information present in the 2024-2027 Red Book. The clinical report reviews the epidemiology of cCMV, clinical manifestations of cCMV disease and cCMV with isolated sensorineural hearing loss (SNHL), diagnosis of cCMV, and treatment of cCMV disease and cCMV with isolated SNHL. The current advantages and disadvantages of different approaches to screening for cCMV infection are reviewed with a recommendation for hearing-targeted (HT) plus expanded testing. Additionally, the initial evaluation for an infant with cCMV and current knowledge of prevention efforts are discussed. Key action statements are provided.
Authors
- Siddharth Srivastava (ORCID: https://orcid.org/0000-0001-7008-1879)
- Jonathan Slaughter (ORCID: https://orcid.org/0000-0002-6401-8547)
- José R. Romero (ORCID: https://orcid.org/0000-0001-8225-0772)
- Betsy C. Herold (ORCID: https://orcid.org/0000-0001-9974-0786)
- Ruchi Kaushik (ORCID: https://orcid.org/0000-0002-6769-2801)
- Robert W. Frenck (ORCID: https://orcid.org/0000-0002-2336-526X)
- Namasivayam Ambalavanan (ORCID: https://orcid.org/0000-0003-0731-9092)
- Eileen Margolies Raynor (ORCID: https://orcid.org/0000-0003-0097-4959)
- Dennis Z. Kuo (ORCID: https://orcid.org/0009-0008-6143-5768)
- Monica I. Ardura (ORCID: https://orcid.org/0000-0002-2853-2581)
- Brenda L. Tesini (ORCID: https://orcid.org/0000-0001-6051-0027)
- Mary T. Caserta (ORCID: https://orcid.org/0000-0002-3813-0762)
- Adam J. Ratner (ORCID: https://orcid.org/0000-0003-1761-794X)
- Roberta L. DeBiasi (ORCID: https://orcid.org/0000-0002-5854-8875)
- Pia S. Pannaraj (ORCID: https://orcid.org/0000-0002-5208-0933)
- Steven E. Sobol
- Claudia Espinosa (ORCID: https://orcid.org/0000-0002-6085-1259)
- Christoph U. Lehmann (ORCID: https://orcid.org/0000-0003-2684-102X)
- Albert H. Park (ORCID: https://orcid.org/0000-0003-0077-6856)
- Deanna S. Bell (ORCID: https://orcid.org/0000-0002-0569-6858)
- Pamela Anne Mudd
- Peggy Elaine Kelley
- Kelly Wade
- Karen Puopolo
- Mandy Brown Belfort
- Samuel Ostrower
- Brian K. Reilly
- Karen M. Puopolo
- Sheryl Frierson
- Robin Blitz
- Ellen Fremion
- Rishi Agrawal
- Jilda Vargus-Adams
- Michelle Melicosta
- Katharine E. Zuckerman
- Kristin Sohl
- Aaron M. Milstone
- Kristina A. Bryant
- C. Mary Healy
- Angela L. Myers
- Kavita Dedhia
- James D. Campbell
- Charleta Guillory
- Thomas Gallagher
- Chandy C. John
- Sean T. O’Leary
- Alanna Windsor
- Matthew Zahn
- Arun Pramanik
- Section on Otolaryngology–Head and Neck Surgery
- Jeffrey Philip Simons
- Margaret Parker
Institutions
- Children's Hospital of Philadelphia (US)
- Children's National (US)
- University of Utah (US)
- University of Utah Hospital (US)
- University of Rochester Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- PEDIATRICS
- Published
- 2026-09-21
- DOI
- https://doi.org/10.1542/peds.2026-078595
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00