Super-enhancer-driven SGK1 activates polyamine metabolism to promote autoimmune uveitis.
) balance, whereas polyamine supplementation negates these therapeutic benefits, confirming SGK1's role in driving disease progression. Notably, through molecular docking and molecular dynamics simulations, we identified herbacetin as a natural inhibitor of SGK1. Herbacetin restores immune balance and mitigates disease severity, highlighting SGK1 as a promising therapeutic target for autoimmune uveitis.
Authors
- Shenqian Tian
- Qi Jiang (ORCID: https://orcid.org/0000-0002-2187-5856)
- Yihan Zhang (ORCID: https://orcid.org/0000-0003-1566-5972)
- Lei Zhu (ORCID: https://orcid.org/0000-0002-2609-0628)
- Jialing Tang (ORCID: https://orcid.org/0000-0001-5031-8031)
- G H Jiang
- Genxian Zhang
- Yue Peng
- Xuling Chen
- Lian Han
- Xingyu Liu
- Siyun Liu
- Yingying Wen
- Zhaohuai Li
- Renbing Jia
- He Li
- Wenru Su
Institutions
- Qinghai University (CN)
- Sun Yat-sen University (CN)
- Bengbu Medical College (CN)
- ShanghaiTech University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-09-18
- DOI
- https://doi.org/10.1126/sciadv.aea6376
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00