Formulation and evaluation of a hydrophilic matrix-based sustained-release tablet of chlorpromazine Hydrochloride

AbstractChlorpromazine hydrochloride (CPZ.HCl) is a first-generation antipsychotic drug with a shortbiological half-life, requiring frequent administration to maintain therapeutic efficacy. Thepresent study aimed to formulate and evaluate hydrophilic matrix-based sustained-release tabletsof chlorpromazine hydrochloride using Hydroxypropyl Methylcellulose (HPMC K4M) as therelease-retarding polymer. The researchers prepared tablets by wet granulation and evaluatedpre-compression and post-compression parameters, including flow properties, hardness,friability, weight variation, thickness, and drug content. In vitro dissolution studies wereperformed using anIP Type I dissolution apparatus to assess the sustained-release behavior ofthe formulations. The results demonstrated satisfactory physicochemical properties andacceptable tablet quality. Formulations with higher concentrations of HPMC K4M sustaineddrug release for up to 12 hours, while FT-IR studies confirmed compatibility between the drugand the selected excipients. The study concluded that HPMC K4M is a suitable hydrophilicpolymer for developing sustained-release chlorpromazine hydrochloride tablets, with thepotential to improve patient compliance and therapeutic effectiveness.