The completion gap framework: age-associated weight gain as passive convergence between meal completion and energy demand

Abstract Age-associated weight gain is commonly attributed to behavioral or metabolic changes. We propose the completion gap framework, in which meal-completion requirements and physiological energy demand are only partially coupled. Persistent mismatch between these variables produces gradual weight gain until a higher equilibrium body weight is reached. This systems-level perspective integrates existing regulatory models while generating experimentally testable predictions for aging, obesity, and nutrition.

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Publication Details

Journal
npj Aging
Published
2026-09-19
DOI
https://doi.org/10.1038/s41514-026-00503-5
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
Type
article
Field-Weighted Citation Impact
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article

The completion gap framework: age-associated weight gain as passive convergence between meal completion and energy demand

Lisheng Cai
npj Aging
Genetics, Aging, and Longevity in Model Organisms
article

The completion gap framework: age-associated weight gain as passive convergence between meal completion and energy demand

Lisheng Cai
article en

Abstract

Abstract Age-associated weight gain is commonly attributed to behavioral or metabolic changes. We propose the completion gap framework, in which meal-completion requirements and physiological energy demand are only partially coupled. Persistent mismatch between these variables produces gradual weight gain until a higher equilibrium body weight is reached. This systems-level perspective integrates existing regulatory models while generating experimentally testable predictions for aging, obesity, and nutrition.

npj Aging
National Institutes of Health (US), Health Resources and Services Administration (US)
Zero hunger
Openalex Percentile: Top 15%
Genetics, Aging, and Longevity in Model Organisms
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