The completion gap framework: age-associated weight gain as passive convergence between meal completion and energy demand
Abstract Age-associated weight gain is commonly attributed to behavioral or metabolic changes. We propose the completion gap framework, in which meal-completion requirements and physiological energy demand are only partially coupled. Persistent mismatch between these variables produces gradual weight gain until a higher equilibrium body weight is reached. This systems-level perspective integrates existing regulatory models while generating experimentally testable predictions for aging, obesity, and nutrition.
Authors
- Lisheng Cai (ORCID: https://orcid.org/0000-0002-9680-8391)
Institutions
- National Institutes of Health (US)
- Health Resources and Services Administration (US)
Publication Details
- Journal
- npj Aging
- Published
- 2026-09-19
- DOI
- https://doi.org/10.1038/s41514-026-00503-5
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00