HCE6-mediated photodynamic therapy induces hepatocellular carcinoma cell death via inhibition of autophagic flux.
study. HCE6 exhibited strong photo-induced cytotoxicity and robust antitumor efficacy. Mechanistically, it appears to induce mitochondrial dysfunction, trigger autophagy, and subsequently impair autophagic flux, ultimately resulting in cell death.
Authors
- Jianhua Zou (ORCID: https://orcid.org/0000-0003-0718-9128)
- Chun Mei Li (ORCID: https://orcid.org/0000-0002-3168-2900)
- Dengfeng Zou (ORCID: https://orcid.org/0000-0003-3406-7820)
- Hongyan Wu (ORCID: https://orcid.org/0000-0002-8221-6766)
- Keyi Zhou (ORCID: https://orcid.org/0000-0002-5353-5995)
- Yiting Shen
- Xintian Huang
- Hong Xue
- Zhiqiang Chen
- Xin Jiang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Guilin Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Southeast University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-09-18
- DOI
- https://doi.org/10.1039/d6tb01034b
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00