Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites.
-complex as a target of bradyzocidal compounds and defined their metabolic impacts on both parasite forms. Our data suggest that mature bradyzoites rely on mitochondrial ATP production.
Authors
- Frank Seeber (ORCID: https://orcid.org/0000-0002-2271-3699)
- Deborah Maus (ORCID: https://orcid.org/0000-0002-9688-2663)
- Martin Blume (ORCID: https://orcid.org/0000-0002-6894-3000)
- Michael Laue
- Tobias Hoffmann
- Elyzana Putrianti
Institutions
- Robert Koch Institute (DE)
Publication Details
- Journal
- PubMed
- Published
- 2026-09-17
- DOI
- https://doi.org/10.7554/elife.102511
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00