Colorectal Polyps and Polyposis Syndromes

Colorectal polyps are mucosal growths that protrude into the lumen of the colon or rectum and vary in histologic type, morphology, and malignant potential. Histologic categories include hyperplastic, inflammatory, hamartomatous, and neoplastic lesions. Sessile polyps emerge directly from the mucosa, while pedunculated polyps are connected by a fibrovascular stalk. This macroscopic categorization reflects morphology. Due to their potential for malignant transformation and their function as antecedents to the majority of colorectal malignancies, neoplastic polyps—especially adenomas—have the highest clinical significance. Age-related increases in incidence make screening and surveillance crucial for early detection and prevention. A crucial tactic for halting the development of adenoma into carcinoma is colonoscopy, which allows for the direct visualization, biopsy, and removal of polyps. Through a thorough examination of etiopathogenesis, classification schemes, diagnostic techniques, and evidence-based management approaches, this educational exercise enhances the clinician's capacity to assess and treat colorectal polyps. Participants learn about risk factors, screening guidelines, and how to recognize inherited polyposis syndromes such Peutz-Jeghers syndrome, Lynch syndrome, familial adenomatous polyposis, and juvenile polyposis. The focus on working together with gastroenterologists, surgeons, pathologists, genetic counsellors, nurses, and other members of the interprofessional team emphasizes coordinated screening, precise diagnosis, genetic risk assessment, and suitable surveillance, all of which improve patient outcomes and early detection.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-18
DOI
https://doi.org/10.5281/zenodo.22824356
Primary Topic
Genetic factors in colorectal cancer
Type
article
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article

Colorectal Polyps and Polyposis Syndromes

Krishna Murthy G., T. Somaiah, Muralinath E., Guruprasad M. et al.
Zenodo (CERN European Organization for Nuclear Research)
Genetic factors in colorectal cancer
article

Colorectal Polyps and Polyposis Syndromes

Krishna Murthy G., T. Somaiah, Muralinath E., Guruprasad M., Mala Kondaiah, Rama Chandraiah, Jenusha, M. Kalyan, Pardiva
article en

Abstract

Colorectal polyps are mucosal growths that protrude into the lumen of the colon or rectum and vary in histologic type, morphology, and malignant potential. Histologic categories include hyperplastic, inflammatory, hamartomatous, and neoplastic lesions. Sessile polyps emerge directly from the mucosa, while pedunculated polyps are connected by a fibrovascular stalk. This macroscopic categorization reflects morphology. Due to their potential for malignant transformation and their function as antecedents to the majority of colorectal malignancies, neoplastic polyps—especially adenomas—have the highest clinical significance. Age-related increases in incidence make screening and surveillance crucial for early detection and prevention. A crucial tactic for halting the development of adenoma into carcinoma is colonoscopy, which allows for the direct visualization, biopsy, and removal of polyps. Through a thorough examination of etiopathogenesis, classification schemes, diagnostic techniques, and evidence-based management approaches, this educational exercise enhances the clinician's capacity to assess and treat colorectal polyps. Participants learn about risk factors, screening guidelines, and how to recognize inherited polyposis syndromes such Peutz-Jeghers syndrome, Lynch syndrome, familial adenomatous polyposis, and juvenile polyposis. The focus on working together with gastroenterologists, surgeons, pathologists, genetic counsellors, nurses, and other members of the interprofessional team emphasizes coordinated screening, precise diagnosis, genetic risk assessment, and suitable surveillance, all of which improve patient outcomes and early detection.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 11%
Genetic factors in colorectal cancer
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Colorectal Polyps and Polyposis Syndromes — Krishna Murthy G., T. Somaiah, et al. · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS