Integrated Single-cell and Bulk Transcriptome Analysis Characterizes a Candidate Ccl4/Lgals3/Egr1 Expression Pattern Associated with Immunometabolic Dysregulation in Traumatic Brain Injury

Traumatic brain injury (TBI) induces neuroimmune activation and metabolic reprogramming in microglia, but the transcriptional regulators underlying these responses remain unclear. This study aimed to integrate single-cell and bulk transcriptomic datasets to identify microglia-associated regulatory genes and characterize their potential roles in post-TBI neuroinflammatory and immunometabolic dysregulation.