Reductive C–O Bond Cleavage and Borylation of Carboxylic Esters
Abstract Alcohols are abundant feedstocks in organic synthesis but remain underutilized as alkyl donors via C–O bond activation. In this work, the deoxygenative Markó–Lam reaction is studied computationally to probe how the reductive radical transformation may be tuned to efficiently furnish open-shell intermediates. The theoretical results were experimentally illustrated for deoxyborylation of a series of benzylic esters.
Authors
- Helena Lundberg (ORCID: https://orcid.org/0000-0002-4704-1892)
- Mårten S. G. Ahlquist (ORCID: https://orcid.org/0000-0002-1553-4027)
- Julius Kuzmin (ORCID: https://orcid.org/0009-0006-8734-9652)
- Julia Rune
- Alexandros Xanthopoulos
Institutions
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- ACS electrochemistry.
- Published
- 2026-09-18
- DOI
- https://doi.org/10.1021/acselectrochem.6c00123
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kungliga Tekniska Högskolan
- Vetenskapsrådet
- Stiftelsen för Strategisk Forskning
- European Research Council