Clinicopathological Evolution of Pyrrolizidine Alkaloid-induced Liver Injury: Transition From SOS to PSVD?
Hepatic sinusoidal obstruction syndrome (SOS) is characterized by hepatic sinusoidal endothelial cell injury and detachment, hepatic sinusoidal congestion, and hepatic cell necrosis. Currently, limited data exist concerning changes during the recovery period, especially histopathological changes. The purpose of this study was to investigate the evolution of pathology in patients with pyrrolizidine alkaloid (PA)-induced SOS and in a monocrotaline-induced SOS rat model.
Authors
- Yuzheng Zhuge (ORCID: https://orcid.org/0000-0002-3829-5831)
- Jiangqiang Xiao (ORCID: https://orcid.org/0009-0009-3074-8929)
- Jingjing Tu
- Han Zhang (ORCID: https://orcid.org/0000-0003-2016-4179)
- Jun Chen (ORCID: https://orcid.org/0000-0003-3905-4615)
- Hui Xu
- Juan Carlos García-Pagán
- Bing Xu
- Lei Wang
- Feng Zhang
- Wei Zhang
- Yao Liu
- Shuyan Zeng
- Si Zhao
- Qin Yin
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2026-09-17
- DOI
- https://doi.org/10.14218/jcth.2026.00077
- Primary Topic
- Plant Toxicity and Pharmacological Properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00