Incidentally detected vertebral fractures and risk of myeloma: a prospective cohort study of 9059 CT-scanned Danish general population individuals
Vertebral fractures are frequently detected incidentally on computed tomography (CT) scans performed for other indications in individuals with no symptoms of a fracture [ 1 ]. In myeloma, >45% of patients have vertebral fractures at the time of myeloma diagnosis [ 2 ]. However, the risk of myeloma in individuals with incidentally detected vertebral fractures is unknown. This lack of evidence has led to a controversy reflected in clinical guidelines, as some recommend evaluation for myeloma by measuring M-protein and kappa/lambda free light chains in all individuals with non-traumatic vertebral fractures [ 3 , 4 ], while other guidelines recommend evaluation only if symptoms or other findings raise suspicion of myeloma [ 5 ].
Authors
- Shoaib Afzal (ORCID: https://orcid.org/0000-0002-1442-4694)
- Anne Rudbeck Juhl (ORCID: https://orcid.org/0000-0003-2457-0182)
- Per Ejlstrup Sigvardsen (ORCID: https://orcid.org/0000-0003-1922-0479)
- Jørgen Tobias Kühl (ORCID: https://orcid.org/0000-0002-7726-689X)
- Michael Huy Cuong Pham (ORCID: https://orcid.org/0000-0002-6577-0079)
- Klaus F. Kofoed (ORCID: https://orcid.org/0000-0001-9742-1554)
- Stig E. Bojesen (ORCID: https://orcid.org/0000-0002-4061-4133)
- Jens Helby (ORCID: https://orcid.org/0000-0002-1876-8187)
- Børge G. Nordestgaard (ORCID: https://orcid.org/0000-0002-1954-7220)
- Andreas Glenthøj (ORCID: https://orcid.org/0000-0003-2082-0738)
- Rasmus Rønnemoes (ORCID: https://orcid.org/0009-0003-0254-6808)
- Thomas S. Kristensen
- Andreas Fuchs Larsen
- Jesper Petersen
Institutions
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Leukemia
- Published
- 2026-09-18
- DOI
- https://doi.org/10.1038/s41375-026-03135-6
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kræftens Bekæmpelse