Perspective a collaborative genomics platform for type 1 diabetes in Eastern and Central Europe

Genomic studies of type 1 diabetes have largely concentrated on Western European and North American cohorts, leaving Eastern and Central European populations under-represented and limiting the portability of genetic risk scores across regional ancestries. We established a resilient, ethically governed type 1 diabetes genomics platform spanning Ukraine and Poland, targeting 20,000 participants. In Ukraine, individuals with clinically confirmed type 1 diabetes and frequency-matched control participants are recruited through 85 physicians across 21 sites. More than 170 harmonised clinical and laboratory variables are captured in REDCap and linked to a biobank, with consent for data release, re-contact and broad molecular profiling. Whole-exome sequencing is performed at the Regeneron Genetics Center (NY, USA), complemented by pilot multi-omic assays. As of April 2026, the cohort comprised 6947 participants with type 1 diabetes and 7036 control participants, with 6363 individuals with type 1 diabetes and 6687 control participants in the complete-data analytic subset. Molecular profiling includes 9666 whole-exome sequences (mean 50.6 ×), with pilot whole-genome, HLA long-read, RNA-seq, microbiome and DNA-methylation datasets under way, all under EU General Data Protection Regulation (GDPR)-compliant controlled access. This platform establishes one of the first large-scale, re-contactable genomic resources for type 1 diabetes in Eastern and Central Europe and offers a transferable model for population-specific research in other under-represented European settings.

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Publication Details

Journal
Metabologia
Published
2026-09-17
DOI
https://doi.org/10.1007/s44357-026-00015-5
Citations
1
Primary Topic
Diabetes and associated disorders
Type
article
Field-Weighted Citation Impact
5.04

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article

Perspective a collaborative genomics platform for type 1 diabetes in Eastern and Central Europe

Yanina Saienko, Yaroslava Hasynets, Anna Z. Czarna, Evgenia Globa et al.
1 citations
Metabologia
Diabetes and associated disorders
5.04
article

Perspective a collaborative genomics platform for type 1 diabetes in Eastern and Central Europe

Yanina Saienko, Yaroslava Hasynets, Anna Z. Czarna, Evgenia Globa, Alan R. Shuldiner, Mykhailo Vakerych, S. Patskun, Iuliia Komisarenko, Sudip Sharma, Dmytro Dziuba, Iryna Kozeretska, Mariia Pavlovska, Joanna Polańska, Yu.V. Buldygina, Roman Nikolaev, N.V. Pasyechko, Paweł P. Łabaj, Svitlana Shkarivska, Violetta Yuzvenko, Khrystyna Shchubelka, V.M. Kulchinska, Tomasz Klupa, Liliia Mogylnytska, Maciej T. Małecki, Л.К. Соколова, Obed Garcia, Joanna Tobiasz, Alina Urbanovych, Volodymyr Smolanka, V. I. Velychko, Oksana Khyzhnyak, Taras Krytskyy, Iryna Tsaryk, Juan L. Rodríguez-Flores, Iryna Kostitska, Pylyp Prudius, Olga Oleksyk, M.I. Bobryk, V.І. Pankiv, Omar E. Cornejo, Stephen S. Rich, N.V. Pashkovska, Chernyshov Vp, Zbigniew Kalarus, Roman Kish, Златослава Олексіївна Шаєнко, Boris Mankovsky, Федір Ланюш, Audrey J. Majeske, Mykhailo Arych, Przemysława Jarosz‐Chobot, Tarás K. Oleksyk, Boris V. Dons’koi, Walter Wolfsberger, Kinga Zielińska, Yurii Savchuk, Mariana Pryima, Viktoriia Yerokhovych, Svitlana Tynta, Oleksii Kurutsa, Karolina Kulis, Sudhir Kumar, Violeta Mirutenko, Natalia Savchuk, T.O. Studeniak, Олександр Дубів, L.A. Turova, Viktoriia Serhiienko, N. Kobyliak, V.H. Neporada, YI Ilkiv, Oksana Anisimova, Halyna Suslyk, Kateryna Malyar, Mariia Hrachova, Anastasia Galetska, Svitlana Sheveria, Natalia Kravchuk, Irina Bondarets, Galyna Chayka, Oksana Marusyn, Valerii Pokrytiuk, Iana Sverdliuk, Nadiia Shylova, Nataliya Kostuk, Hanna Pencho, Inna Semeniuk, Myroslava Kachur, Maryna Chukmasova, Alina Huklyvska, Diana Suvorova, Iryna Trompinska, Sebastian Seget
article en
1 citations

Abstract

Genomic studies of type 1 diabetes have largely concentrated on Western European and North American cohorts, leaving Eastern and Central European populations under-represented and limiting the portability of genetic risk scores across regional ancestries. We established a resilient, ethically governed type 1 diabetes genomics platform spanning Ukraine and Poland, targeting 20,000 participants. In Ukraine, individuals with clinically confirmed type 1 diabetes and frequency-matched control participants are recruited through 85 physicians across 21 sites. More than 170 harmonised clinical and laboratory variables are captured in REDCap and linked to a biobank, with consent for data release, re-contact and broad molecular profiling. Whole-exome sequencing is performed at the Regeneron Genetics Center (NY, USA), complemented by pilot multi-omic assays. As of April 2026, the cohort comprised 6947 participants with type 1 diabetes and 7036 control participants, with 6363 individuals with type 1 diabetes and 6687 control participants in the complete-data analytic subset. Molecular profiling includes 9666 whole-exome sequences (mean 50.6 ×), with pilot whole-genome, HLA long-read, RNA-seq, microbiome and DNA-methylation datasets under way, all under EU General Data Protection Regulation (GDPR)-compliant controlled access. This platform establishes one of the first large-scale, re-contactable genomic resources for type 1 diabetes in Eastern and Central Europe and offers a transferable model for population-specific research in other under-represented European settings.

MetabologiaVol. 2(1)
Silesian University of Technology (PL), Jagiellonian University (PL), National University of Food Technologies (UA), Ivano-Frankivsk National Medical University (UA), University of Kansas (US), West Ukrainian National University (UA), Khmelnytskyi National University (UA), Medical University of Silesia (PL), Odessa National Medical University (UA), Oakland University (US), University of California, Santa Cruz (US), Regeneron (United States) (US), Taras Shevchenko National University of Kyiv (UA), Cornell University (US), Danylo Halytsky Lviv National Medical University (UA), Shupyk National Healthcare University of Ukraine (UA), Bukovinian State Medical University (UA), State Institution National Antarctic Scientific Center (UA), State Institution "Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine" (UA), Cherkasy State Technological University (UA), State Institution «Academician O.F.Vozianov Institute of Urology of the National Academy of Medical Sciences of Ukraine» (UA), Poltava V.G. Korolenko National Pedagogical University (UA), V.P. Komisarenko Institute of Endocrinology and Metabolism (UA), D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA), City Clinical Hospital (RU), National Academy of Medical Sciences of Ukraine (UA), Kyiv City Clinical Oncology Center (UA), Regional Clinical Hospital named after II Mechnikov (UA), I.Horbachevsky Ternopil National Medical University (UA), Ministry of Health (RW), Weill Cornell Medicine (US), Poltava State Medical University (UA), University of Virginia (US), Uzhhorod National University (UA), Temple University (US), Bogomolets National Medical University (UA)
Leona M. and Harry B. Helmsley Charitable Trust
Openalex Percentile: Top 4%
Diabetes and associated disorders
5.04
DOIOpen Access PDFOpenAlex
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