The Treadmill Prescription: The c-Fos–SIRT6 Epigenetic Axis as a Host-Encoded Bio-Medicine for Genomic Stability, Anti-Inflammation, and Lifespan Extension

{"Abstract":[0],"Physical":[1],"exercise":[2,23,163,188],"via":[3],"treadmill":[4,148,263],"running":[5,65,149],"is":[6],"traditionally":[7],"prescribed":[8],"for":[9,158,252],"cardiovascular":[10],"conditioning":[11],"and":[12,28,140,165,195,230,260],"metabolic":[13],"management.":[14],"However,":[15],"the":[16,75,89,102,116,136,177,233,249],"precise":[17],"neuro-epigenetic":[18],"mechanisms":[19],"linking":[20],"regular":[21],"mechanical":[22,186],"to":[24,54,189,216],"systemic":[25],"genomic":[26],"stability":[27],"cellular":[29],"longevity":[30],"remain":[31],"under-characterized.":[32],"Here,":[33],"we":[34],"synthesize":[35],"key":[36],"neurobiological":[37],"findings":[38],"from":[39,49],"Kim":[40],"et":[41,51],"al.":[42,52],"(2004)":[43],"with":[44,155],"fundamental":[45],"cancer":[46],"initiation":[47],"pathways":[48],"Min":[50],"(2012)":[53],"establish":[55],"a":[56,151,181],"unified":[57],"molecular":[58,183],"model:":[59],"The":[60],"Treadmill-Induced":[61],"c-Fos–SIRT6":[62,178],"Axis.":[63],"Treadmill":[64],"(30":[66],"minutes":[67],"daily)":[68],"induces":[69],"immediate-early":[70],"gene":[71],"c-Fos":[72,85,110,204],"expression":[73],"in":[74,88,96,101,209,214],"mammalian":[76],"hippocampus":[77],"across":[78],"all":[79],"age":[80],"demographics.":[81],"In":[82],"young":[83],"organisms,":[84,98],"induction":[86,99,205],"peaks":[87,100],"Cornu":[90],"Ammonis":[91],"(CA)":[92],"region,":[93],"driving":[94],"neuroplasticity;":[95],"aging":[97],"Dentate":[103,212],"Gyrus":[104,213],"(DG),":[105],"reactivating":[106],"neurogenic":[107],"capacity.":[108],"Downstream,":[109],"directly":[111],"transactivates":[112],"SIRT6":[113,123,226],"(Sirtuin":[114],"6),":[115],"chromatin-bound":[117],"master":[118],"regulator":[119],"of":[120,228,235],"longevity.":[121],"Elevated":[122],"drives":[124],"histone":[125],"H3K9":[126],"deacetylation":[127],"(H3K9ac":[128],"→":[129],"H3K9me),":[130],"accelerates":[131],"double-strand":[132,192],"DNA":[133,193],"repair,":[134,194],"suppresses":[135],"anti-apoptotic":[137],"oncogene":[138],"survivin,":[139],"attenuates":[141],"pro-inflammatory":[142],"NF-κB":[143],"signaling.":[144,197],"This":[145],"work":[146],"establishes":[147],"as":[150,180],"non-pharmacological,":[152],"host-encoded":[153],"bio-medicine":[154],"broad":[156],"implications":[157],"public":[159],"health":[160],"policy,":[161],"clinical":[162],"prescription,":[164],"multi-generational":[166],"preventive":[167],"healthcare.":[168],"Key":[169],"Highlights":[170],"&":[171,221,244,270],"Translational":[172,174],"Impact":[173],"Epigenetics:":[175],"Identifies":[176],"axis":[179],"primary":[182],"bridge":[184],"connecting":[185],"aerobic":[187],"chromatin":[190],"remodeling,":[191],"anti-inflammatory":[196],"Multi-Generational":[198],"Brain":[199],"Optimization:":[200],"Demonstrates":[201],"age-dependent":[202],"hippocampal":[203],"shifts":[206],"(CA":[207],"region":[208],"youth":[210],"vs.":[211],"aging)":[215],"reactivate":[217],"dormant":[218],"neurogenesis.":[219],"Oncogenic":[220],"Inflammatory":[222],"Suppression:":[223],"Details":[224],"exercise-induced":[225],"repression":[227],"survivin":[229],"NF-κB,":[231],"facilitating":[232],"elimination":[234],"initiated":[236],"pre-cancerous":[237],"cells":[238],"while":[239],"shielding":[240],"healthy":[241],"tissue.":[242],"B2B":[243],"Public":[245],"Health":[246],"Application:":[247],"Provides":[248],"scientific":[250],"foundation":[251],"\\"prescription":[253],"exercise\\"":[254],"frameworks,":[255],"state-subsidized":[256],"home":[257],"equipment":[258],"programs,":[259],"next-generation":[261],"smart":[262],"console":[264],"integrations":[265],"(SIRT6":[266],"Activation":[267],"Score).":[268],"Affiliation":[269],"Institutional":[271],"Contact":[272],"Genome-2-BioMedicine":[273],"Discovery":[274],"Center":[275],"(GBMD),":[276],"GenomeDiscovery.Org,":[277],"Puducherry,":[278],"India":[279],"Corresponding":[280],"Author:":[281],"Dr.":[282],"L.":[283],"Boominathan,":[284],"PhD":[285],"([email protected]":[286],"|":[287],"[email protected]):":[288],"X:":[289],"@drlboominathan":[290]}