Spectrum of Gluten Intolerance

The spectrum of gluten intolerance spans celiac disease, dermatitis herpetiformis, nonceliac gluten sensitivity, and wheat allergy. These conditions share gluten as the driver perpetuating symptoms and pathology. This review seeks to compare and contrast the main conditions on the spectrum of gluten intolerance with respect to definition, epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment.

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Publication Details

Journal
Annual Review of Medicine
Published
2026-09-17
DOI
https://doi.org/10.1146/annurev-med-042425-020731
Primary Topic
Celiac Disease Research and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Spectrum of Gluten Intolerance

Claire Jansson‐Knodell, Alberto Rubio-Tapia
Annual Review of Medicine
Celiac Disease Research and Management
article

Spectrum of Gluten Intolerance

Claire Jansson‐Knodell, Alberto Rubio-Tapia
article en

Abstract

The spectrum of gluten intolerance spans celiac disease, dermatitis herpetiformis, nonceliac gluten sensitivity, and wheat allergy. These conditions share gluten as the driver perpetuating symptoms and pathology. This review seeks to compare and contrast the main conditions on the spectrum of gluten intolerance with respect to definition, epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment.

Annual Review of Medicine
Cleveland Clinic (US)
Good health and well-being
Openalex Percentile: Top 9%
Celiac Disease Research and Management
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Spectrum of Gluten Intolerance — Claire Jansson‐Knodell, Alberto Rubio-Tapia · Annual Review of Medicine (2026) | TGRS Research Map | TGRS